Contact details:

8A University Health Center
4201 St. Antoine
Detroit, MI 48201
USA

Recent Publications:

Shy ME, Peripheral Neuropathies, In Cecil23 Textbook of Medicine, Goldman and Lee eds, , Saunders/Elsevier, Philadelphia, 2802-2817, 2007

Kamholz J, Brucal M, Li J, Shy ME, Myelin Protein Zero and CMT1B: a tale of two phenotypes, in Molecular Neurology, Waxman S ed. Elsevier Press, Burlington Vt, San Diego CA, London UK, 463-475, 2007

Shy ME, Kamholz J, Li J, Mutations in Schwann cell genes causing inherited neuropathies, In The Biology of Schwann Cells,; Development, Differentiation and Immunomodulati9n, Armati PJ ed, Cambridge U. Press, 126-157, 2007

Padua L, Shy ME, Aprile I, Cavallaro T, Pareyson D, Quattrone A, Rizzuto N, Vita G, Tonali P, Schenone A, Correlation between clinical/neurophysiological findings and quality of life in Charcot Marie Tooth Type 1A, Journal of the Peripheral Nrvous System, 13: 64-70, 2008,

Shy ME, Chen L, Swan E, Taube R, Krajewski KM, Herrmann D, Lewis RA, McDermott MP, Neuropathy Progression in Charcot Marie Tooth Disease Type 1A (CMT1A), Neurology, 70: 378-383

K.W.Chung, PhD,1 B.C.Suh, MD,2 M.E.Shy, MD,3 S.Y.Cho, PhD,4 J.H.Yoo, MD,5 J.S.Suh, MD,5 J.Kim, PhD,1 H.Moon, MD,2 K.-D.Park, MD,4 K.G.Choi, MD,4 S.Kim,6 D.S.Shim, MD,7 S.M.Kim, MD,7 I.N.Sunwoo, MD,7 B.-O.Choi, MD 4, Different clinical and magnetic resonance imaging fetures between Charcot Marie Tooth disease type 1A and 2A, Neuromuscular Disorders, In Press

Grandis M, Vigo T, Jain M, Brucal M, Passalacqua M, La Padula V, Benvenuto F, Cadoni A, Kamholz J, Shy ME and Schenone A, Defferent Cellular and Molecular Mechanisms for early and late onset myelin protein zero mutations, Hum Mol Gen, 17: 1877-1889, 2008

Zhang X, Chow CY, Sahenk Z, Shy ME, Meisler MH, Li J, Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration, Brain, 1990-2001, 2008

Gooch C and Shy ME, Hereditary motor neuropathy and heat shock proteins: a shocking transformation, Editorial, Neurology, In Press.

Michael E. Shy MD

Professor of Neurology Professor of Molecular Medicine and Genetics Director of CMT Program Co-Director of Neuromuscular Division and Co-Director of Neurogenetics Wayne State University School of Medicine

Michael Shy MD


Michael Shy is an internationally recognized expert in the inherited peripheral neuropathies collectively known as Charcot Marie Tooth disease (CMT). He received his BA at the University of Pennsylvania and his MD from Albany Medical College in Albany New York. Dr. Shy did his Neurology training and a fellowship at the Neurological Institute of the Columbia Presbyterian Medical Center in New York City.
He was previously on the faculty of the Thomas Jefferson University in Philadelphia prior to moving to Wayne State University in 1994. Dr. Shy directs the translational research program at Wayne State that combines laboratory studies of animal and cellular models of various forms with CMT with one of the largest clinics in the world evaluating, treating and investigating patients with CMT. Dr Shy’s research is funded by the National Institutes of Health, the Muscular Dystrophy Association and the Charcot Marie Tooth Association. Dr. Shy serves as the Chair of the Scientific Advisory Board of the Charcot Marie Tooth Association (CMTA) and also co-chairs the Star initiative of the CMTA that is directed towards identifying novel therapies for various forms of CMT. Dr. Shy serves on the Medical Advisory Board of the Muscular Dystrophy Association and also on the national committee of the MDA to develop transitional care for children developing into adulthood with neuromuscular disease. Dr. Shy directs the NIH supported Rare Disease Clinical Research Consortium (RDCRC) on inherited neuropathies. He is also PI of the North American CMT Network, supprted by the MDA and CMTA. He has published more than 100 articles, chapters and reviews, particularly on the inherited neuropathies.