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Dr Richard Orrell
Senior Lecturer in Clinical Neurosciences
Department of Clinical Neurosciences,
University College London
 Research Interests
Neuromuscular Disorders and Neurodegnerative Diseases, MND/ALS, muscular dystrophy, neuropathy, genetics
Research Description
My research theme is focussed on neuromuscular disorders, neurodegenerative disorders, and neurogenetics. Within neuromuscular disorders I am interested in motor neuron disease / amyotrophic lateral sclerosis, muscular dystrophies, neuropathies, and related conditions. Current research projects include mitochondrial function in ALS, the neurotrophic effects of mechanogrowth factor (MGF) in ALS and other disorders, and genetic analysis of ALS. In addition to laboratory research, I provide a clinical service in neuromuscular disorders, including my role as Co-Director of the Motor Neuron Disease Care and Research Centre at the National Hospital for Neurology and Neurosurgery, and motor neuron disease, muscle and nerve disorder clinics at the Royal Free Hospital. I perform muscle and nerve biopsies, and EMG, and contribute to the reporting of peripheral nerve biopsies. As co-lead for motor neuron disease in the North Thames Department of Health funded Dementia and Neurodegenerative Diseases Research Network (DeNDRoN), I am developing a structure for clinical and other research projects. I am lead of the UCL Motor Neuron Disease Research Interest Group.
Conditions
Charcot-Marie-Tooth disease, Chronic inflammatory demyelinating polyneuropathy, Dementia - frontotemporal, Disorders of neuromuscular junction transmission, Disorders of striated muscle, Environmental toxins, Guillain-Barr� syndrome, Leukodystrophies, Metabolic myopathies, Motor neuron disease, Muscular dystrophy, Myelopathies, Myotonia, Neuropathy, Neurodegenerative diseases, Primary progressive aphasia
Methods
Cell culture, Diffusion tensor imaging (DTI), Electromyography, Electron Microscopy, Enzyme assays, Genetic screens, Genomic analyses, Histology, Image analysis, Immunohistochemistry, Linkage, mapping and positional cloning, Magnetic resonance imaging (MRI), miRNA analysis, Randomized Controlled Trials (RCTs), Transgenic mice, Proteomics
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Contact details
Department of Clinical Neurosciences,
Institute of Neurology,
University College London,
Rowland Hill
London NW3 2PF
Telephone +44 (0)20 7830 2387
Internal Telephone x32387
Fax +44 (0)20 7472 6829
Email r.orrell@medsch.ucl.ac.uk
Recent Publications
Scott,K.M., Abhinav,K., Stanton,B.R., Johnston,C., Turner,M.R.,
Ampong,M.A., Sakel,M., Orrell,R.W., Howard,R., Shaw,C.E.,
Leigh,P.N., Al-Chalabi,A. (2009). Geographical clustering of
amyotrophic lateral sclerosis in South-East England: a
population study. Neuroepidemiology 32(2), 81-88.
ISSN: 0251-5350
Bacsi,A.M., Ginsberg,L., Orrell,R.W. (2008). Reversible
dysphagia in facioscapulohumeral dystrophy caused by
myasthenia gravis. Journal of Neurology, Neurosurgery and
Psychiatry 79(3), 358-358
Orrell,R.W., Lane,R.J., Ross,M. (2008). A systematic review
of antioxidant treatment for amyotrophic lateral sclerosis/
motor neuron disease. Amyotrophic Lateral Sclerosis 9(4),
195-211. ISSN: 1748-2968
Ates,K., Yang,S.Y., Orrell,R.W., Sinanan,A.C., Simons,P.,
Solomon,A., Beech,S., Goldspink,G., Lewis,M.P. (2007).
The IGF-I splice variant MGF increases progenitor cells in ALS,
dystrophic, and normal muscle. FEBS Letters 581(14), 2727-2732.
ISSN: 0014-5793
Orrell,R.W. (2007). Endocrine myopathies. Chapter 17 in Mastaglia,F.L.,
Hilton-Jones,D. (ed.) Myopathies. Handbook of Clinical Neurology,
Voume 86 series. , 343-355. ISBN: 9780444518996
Bradley,L.J., Wilhelm,T., King,R.H., Ginsberg,L., Orrell,R.W. (2006).
Brachial plexus hypertrophy in chronic inflammatory demyelinating
polyradiculoneuropathy. Neuromuscular Disorders 16(2), 126-131.
ISSN: 0960-8966
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