Professor Adrian Thrasher

Professor Adrian Thrasher, MB BS PhD MRCPCH FRCP FMedSCi

Wellcome Trust Senior Clinical Fellow
NIHR Senior Investigator
Consultant Immunologist GOSH
Director of Centre for Immunodeficiency
Director of Gene Therapy Programme ICH/GOSH

Professor Thrasher's clinical interests are the diagnosis and treatment of patients with primary immunodeficiency. He has a specialist interest in the Wiskott-Aldrich Syndrome (WAS), disorders of innate immunity, and Autoimmune Lymphoproliferative Syndrome. He is also conducting trials of somatic gene therapy for various forms of PID including SCID-X1, CGD, ADA-SCID, and WAS. His research interests include the pathophysiology of primary immunodeficiency syndromes especially WAS, the actin cytoskeleton in haematopoietic cells (with Dr Siobhan Burns), the development of somatic gene therapy (with Professor Bobby Gaspar, Professor Christine Kinnon, Dr Waseem Qasim, and for ocular disease with Professor Robin Ali), and thymus transplantation (with Dr Graham Davies).

Contact details

Institute of Child Health
30 Guildford Street
London WC1N 1EH

Email: a.thrasher@ich.ucl.ac.uk

Links

www.ich.ucl.ac.uk/ich/academicunits/Molecular_immunology/
Homepage

www.centreforimmunodeficiency.com/.

Selected publications

Ali, R.R., G. Sarra, C. Stephens, M. de Alwis, J. W.B. Bainbridge,
P. M. Munro, S. Fauser, M. B. Reiche1, C. Kinnon, D. M. Hunt,
S. S. Bhattacharya, Thrasher, A.J. Restoration of photoreceptor
ultrastructure and function in retinal degeneration slow mice by
gene therapy. Nature Genet. 25: 306-310, 2000.

Thrasher, A.J. WASp in immune-system organization and function.
Nat Rev Immunol. 2(9):635-46, 2002.

Cavazzana-Calvo, M., Thrasher, A.J., Mavilio, F. The future of
gene therapy. Nature, 427: 779-781, 2004.

Gaspar, H.B., Parsley, K/. Howe, S., King, D., Gilmour, K., Sinclair, J.,
Brouns, G., Schmidt, M., Von Kalle, C., Barington, T., Jacobsen, M.,
Christensen, H.O., AlGhonaim, A., White, H., Smith, J., Levinsky,
R., Ali, R.R., Kinnon, C., Thrasher, A.J. Gene therapy of X-linked
severe combined immunodeficiency using a pseudotyped
gammaretroviral vector. Lancet 364: 2181-2187, 2004.

Yanez, R., Balaggan, K., MacNeil, A., Smith, A.J., Buch, P., Howe, S.,
Duran, Y., Maclaren, R.E., Anderson, P., Kinnon, C., Ali, R.R.,
Thrasher, A.J. Effective gene therapy with non-integrating lentiviral
vectors Nature Medicine 12: 348-353, 2006

Ott, M., Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U,
Glimm H, Kuhicke K, Schilz A, Kunkel H, Naundorf S, Brinkmann A,
Deichmann A, Fischer M, Ball C, Pilz I, Dunbar C, Du Y, Jenkins NA,
Copeland NG, Luthi U, Hassan M, Thrasher AJ, Hoelzer D, von Kalle C,
Seger R, & Grez M. Correction of X-linked chronic granulomatous
disease by gene therapy, augmented by insertional activation of
MDS1-EV11, PRDM16 or SETBP1. Nature Medicine 12(4), 401-409, 2006.

Gaspar, H.B., Bjorkegren^,E., Parsley, K., Gilmour, K., King, D.,
Sinclair^,J., Adams^,S., Fairbanks^,L.D., GasparJ., Henderson^,L.,
Davies, E.G., Veys, P., Kinnon^,C., Thrasher, A.J. Successful
reconstitution of immune function in ADA-SCID by stem cell gene
therapy following cessation of PEG-ADA and use of mild pre-conditioning.
Mol. Ther 14(4): 505-513, 2006.

Thrasher A; Gaspar H; Baum C; Modlich U; Schambach A; Candotti F;
Otsu M; Sorrentino B; Scobie L; Cameron E; Blyth K; Neil J;
Hacein-Bey Abina S; Cavazzana-Calvo M; Fischer A. Gene Therapy:
SCID-X1 transgene leukaemogenicity. Nature, 443, E5-E6, 2006

Schwarzwaelder, K., Howe, S.J., Schmidt, M., Brugman, M.,
Deichmann, A., Glimm, H., Schmidt, S., Prinz, C., Wissler, M.,
King, D.J.S., Zhang, F., Parsley, K.L., Gilmour, K.C., Sinclair, J.,
Bayford, J., Peraj, R., de Ridder, D., Pike-Ovezet, K., Wagemaker, G.,
Kinnon, C., Abel, U., Staal, F., Gaspar, H.B., Thrasher, A.J. (joint senior author),
von Kalle, C. Gammaretrovirus-mediated correction of SCID-X1 is associated
with skewed vector integration site distribution in vivo. J.Clin.Inv,117 (8),
2241-2249, 2007

Moulding, D.A., Blundell, M.P., Spiller, D.G., White, M.R.H., Cory, G.O.,
Calle, Y., Kempski, H., Sinclair, J., Ancliff, P.J., Kinnon, C., Jones, G.E.,
Thrasher, A.J. Unregulated actin polymerization by WASp causes defects
of mitosis and cytokinesis in X-linked neutropenia. J.Exp.Med, 204(9):
2213-2224, 2007.